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Gardel, Margaret
One or more keywords matched the following properties of Gardel, Margaret
PropertyValue
keywords Adhesion, Cell
overview My lab is dedicated to understanding how cell adhesion and migration is regulated by the physical behaviors and structure of the actin cytoskeleton, focal adhesions and cell-cell adhesions and how the physical behaviors of complex cytoskeletal machines emerge from their molecular constituents. We employ approaches from condensed matter physics, cell biology and biochemistry to study the physical properties of the actin cytoskeleton and focal adhesions within live cells and in reconstituted systems of purified proteins.
One or more keywords matched the following items that are connected to Gardel, Margaret
Item TypeName
Concept Cell Adhesion
Concept Focal Adhesions
Concept Cell Adhesion Molecules
Concept Focal Adhesion Kinase 1
Concept Focal Adhesion Kinase 2
Academic Article Endothelial barrier disruption and recovery is controlled by substrate stiffness.
Academic Article Myosin II-mediated focal adhesion maturation is tension insensitive.
Academic Article Model for adhesion clutch explains biphasic relationship between actin flow and traction at the cell leading edge.
Academic Article Dynamic and structural signatures of lamellar actomyosin force generation.
Academic Article Regulation of cell motile behavior by crosstalk between cadherin- and integrin-mediated adhesions.
Academic Article Optimization of traction force microscopy for micron-sized focal adhesions.
Academic Article Mechanical integration of actin and adhesion dynamics in cell migration.
Academic Article Biophysics. Clutch dynamics.
Academic Article Probing intracellular force distributions by high-resolution live cell imaging and inverse dynamics.
Academic Article Contact guidance requires spatial control of leading-edge protrusion.
Academic Article Spatiotemporal constraints on the force-dependent growth of focal adhesions.
Academic Article Transient frictional slip between integrin and the ECM in focal adhesions under myosin II tension.
Academic Article Lamellipodium is a myosin-independent mechanosensor.
Academic Article Dia1-dependent adhesions are required by epithelial tissues to initiate invasion.
Academic Article Geometry regulates traction stresses in adherent cells.
Academic Article Stressing the limits of focal adhesion mechanosensitivity.
Academic Article Arp2/3 inhibition induces amoeboid-like protrusions in MCF10A epithelial cells by reduced cytoskeletal-membrane coupling and focal adhesion assembly.
Academic Article Cell-ECM traction force modulates endogenous tension at cell-cell contacts.
Academic Article Preparation of complaint matrices for quantifying cellular contraction.
Academic Article Traction stress in focal adhesions correlates biphasically with actin retrograde flow speed.
Academic Article Protrusive activity guides changes in cell-cell tension during epithelial cell scattering.
Academic Article F-actin buckling coordinates contractility and severing in a biomimetic actomyosin cortex.
Academic Article United we stand: integrating the actin cytoskeleton and cell-matrix adhesions in cellular mechanotransduction.
Academic Article Tension is required but not sufficient for focal adhesion maturation without a stress fiber template.
Academic Article Cell-substrate interactions.
Academic Article A zyxin-mediated mechanism for actin stress fiber maintenance and repair.
Academic Article Conserved F-actin dynamics and force transmission at cell adhesions.
Academic Article PyK2 and FAK connections to p190Rho guanine nucleotide exchange factor regulate RhoA activity, focal adhesion formation, and cell motility.
Academic Article Force localization modes in dynamic epithelial colonies.
Academic Article Dia1 coordinates differentiation and cell sorting in a stratified epithelium.
Academic Article Force-dependent intercellular adhesion strengthening underlies asymmetric adherens junction contraction.
Academic Article Force-dependent intercellular adhesion strengthening underlies asymmetric adherens junction contraction.
Grant Mechanical Regulation of Cell Adhesion by Dynamic Cytoskeletal Assemblies
Grant 2007 NIH Director's Pioneer Award Program (DP1)
Academic Article Machine learning interpretable models of cell mechanics from protein images.
Search Criteria
  • substrate
  • adhesion